Precursor Bcell Acute Lymphoblastic Leukemia

- 17.08

Details: ACC-727
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Precursor B-cell lymphoblastic leukemia is a form of lymphoid leukemia in which too many B-cell lymphoblasts (immature white blood cells) are found in the blood and bone marrow. It is the most common type of acute lymphoblastic leukemia (ALL). It is sometimes additionally classified as a lymphoma, as designated leukemia/lymphoma.

It consists of the following subtypes:

  • t(9;22)-BCR/ ABL
  • t(v;11q23)-MLL rearrangement
  • t(1;19)-E2A/PBX1
  • t(12;21)-ETV/ CBF?
  • t(17;19)-E2A-HLF


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Maps, Directions, and Place Reviews



Molecular Mechanisms

One interesting model of precursor B ALL shows aberrant function of a single gene, namely Pax5, as capable to change phenotype of B cells toward precursor cells.


Precursor Bcell Acute Lymphoblastic Leukemia Video



Diagnosis


The importance of immunophenotyping by flow cytometry in ...
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Treatment

Source of the article : Wikipedia



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